Natural Pet Anxiety ProbioticCalm Supplement for Dogs & Cats
Is your dog anxious, hyperactive, or stressed? The gut-brain connection is real for dogs too. ECS Probiotic 40 uses endocannabinoid-stimulating probiotics to support calm behavior naturally.
Is your dog experiencing:
- Anxiety during storms, fireworks, or separation
- Hyperactive, can't settle or relax
- Excessive barking or destructive behavior
- Nervousness around people or other dogs

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The Gut-Brain Connection in Dogs
Research shows that 90% of serotonin (the "calm hormone") is produced in the gut. A healthy gut microbiome = a calmer, happier dog.
Support Mood Balance
40 Billion CFU of strains that support serotonin production for natural calm and contentment
Activate ECS
Endocannabinoid system regulation helps reduce anxiety responses and stress reactivity
Improve Behavior
Balanced gut microbiome supports better impulse control and reduced hyperactivity
What to Expect
Your dog's journey to calm behavior
Week 1-2
Initial gut colonization, slight calming
Week 3-4
Noticeable reduction in anxiety behaviors
Month 2-3
Improved impulse control, calmer demeanor
Ongoing
Long-term mood and behavior support
Happy Dogs, Happy Pet Parents
Real results from dogs just like yours
"My Lab was terrified of thunderstorms. After 3 weeks on ECS Probiotic 40, he barely reacts now! Total game-changer."
— Sarah M., Labrador mom
"Our rescue pit bull was so anxious. This probiotic has helped him relax and trust us. He's like a different dog!"
— Mike R., Pit Bull dad
"My hyperactive Border Collie can finally settle down. The destructive chewing has stopped completely!"
— Jennifer K., Collie owner
The Dogs That Calmed Themselves
How research beagles led to a breakthrough in anxiety relief
During a federally-funded metabolic research study, control group animals receiving standard probiotic supplementation exhibited unexpected behavioral changes that weren't part of the study's primary endpoints. Veterinary staff documented significant reductions in vocalization patterns, improved stress markers, and normalized cortisol levels over a two-week period.
Subsequent metabolic analysis revealed elevated endocannabinoid precursors and short-chain fatty acids in serum samples—compounds known to modulate anxiety and inflammatory responses through the endocannabinoid system.
The findings were documented in internal reports but never published in peer-reviewed literature. According to researchers familiar with the study, the data showed promise for veterinary applications but didn't align with the pharmaceutical sponsor's development priorities at the time.
📚 Scientific Context:
Independent research has demonstrated that specific bacterial strains can modulate endocannabinoid signaling through metabolite production (Zoetendal et al., 2012, Science; Desbonnet et al., 2010). These mechanisms appear consistent across mammalian species.
Strain identification data from similar research programs eventually became available to the scientific community. Modern formulations leverage these insights, applying peer-reviewed microbiome-endocannabinoid research to veterinary wellness applications.
Research-grade bacterial strains, originally characterized for their endocannabinoid-modulating properties, now formulated specifically for companion animal wellness.
Easy to Give, Great Results
Small Dogs (Under 25 lbs)
½ capsule daily (open and sprinkle on food)
Medium Dogs (25-50 lbs)
1 capsule daily with food
Large Dogs (Over 50 lbs)
1-2 capsules daily with food
💡 Tip: Open capsule and mix powder with wet food, yogurt, or peanut butter
Pet Anxiety Probiotic FAQs
Common questions from pet owners about calming probiotics
What is a pet anxiety probiotic?⌄
A pet anxiety probiotic contains beneficial bacteria that support the gut-brain axis in dogs and cats. Since 90% of serotonin (the calm hormone) is produced in the gut, a healthy microbiome directly affects your pet's mood and behavior. These probiotics produce metabolites that support endocannabinoid system function, helping reduce stress responses and promote natural calm.
How does a calming probiotic for dogs work?⌄
A calming probiotic for dogs works through the gut-brain connection. Beneficial bacteria produce neurotransmitter precursors, regulate stress hormones like cortisol, support endocannabinoid signaling, and reduce inflammatory markers that contribute to anxiety. This natural approach addresses the root cause of stress behaviors rather than just masking symptoms.
Is this safe for my dog or cat?⌄
Yes! ECS Probiotic 40 uses only GRAS (Generally Recognized as Safe) probiotic strains that are safe for pets. It contains no cannabis, THC, or CBD—only beneficial bacteria that support your pet's own endocannabinoid production. The formula is manufactured in a GMP-certified facility. As with any supplement, consult your veterinarian, especially if your pet has underlying health conditions or is on medication.
What is a dog stress supplement?⌄
A dog stress supplement helps manage anxiety-related behaviors through natural ingredients. Probiotic-based stress supplements work by supporting gut health, which in turn regulates mood through the gut-brain axis. This approach is gentler than pharmaceutical options and addresses the biological foundation of stress responses without sedation or side effects.
How do I give this to my pet?⌄
ECS Probiotic 40 capsules are easy to give! Simply open the capsule and sprinkle the powder over your pet's food, mix it with wet food, yogurt, or peanut butter. Most pets don't notice any taste change. Dosing: Small dogs (under 25 lbs) get ½ capsule daily, medium dogs (25-50 lbs) get 1 capsule, and large dogs (over 50 lbs) get 1-2 capsules. Consistent daily use provides best results.
When will I see results in my pet?⌄
Most pet owners notice initial calming effects within 2-4 weeks as the probiotic strains colonize the gut. Digestive improvements often appear first, followed by gradual behavioral changes like reduced anxiety during storms, less destructive behavior, and better impulse control. For sustained benefits and maximum gut-brain axis support, continue use for at least 60-90 days.
Give Your Dog the Gift of Calm
Natural gut-brain support for anxious, hyperactive dogs. 30-day money-back guarantee.
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